GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2273905 | 1 | rs1190554 | chr14:102918686 | ANKRD9 | chr14:102973198-102976128:- | 0.12 | 3.81 | 0.000145 | QT interval |
| BRCA | cis | rs867186 | 1 | rs11906148 | chr20:33784021 | MMP24 | chr20:33814539-33864804:+ | -0.22 | -3.71 | 0.00022 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs11906148 | chr20:33784021 | PROCR | chr20:33758727-33765164:+ | -0.25 | -4.89 | 1.14E-6 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs11907010 | chr20:33737661 | MMP24 | chr20:33814539-33864804:+ | -0.24 | -3.97 | 7.78E-5 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs11907010 | chr20:33737661 | PROCR | chr20:33758727-33765164:+ | -0.28 | -5.42 | 7.52E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs11907011 | chr20:33767770 | PROCR | chr20:33758727-33765164:+ | -0.24 | -4.78 | 1.96E-6 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs11908683 | chr20:33720920 | MMP24 | chr20:33814539-33864804:+ | -0.22 | -3.77 | 0.000172 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs11908683 | chr20:33720920 | PROCR | chr20:33758727-33765164:+ | -0.28 | -5.54 | 3.88E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs13064954 | 1 | rs11917697 | chr3:156967568 | LEKR1 | chr3:156544076-156763918:+ | -0.24 | -3.44 | 0.000609 | Smoking cessation in chronic obstructive pulmonary disease;Diabetic retinopathy |
| BRCA | cis | rs10935120 | 1 | rs11919350 | chr3:134235970 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.17 | 8.07E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs11919350 | chr3:134235970 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.69 | 0.000238 | Height |
| BRCA | cis | rs11920570 | 1 | rs11920570 | chr3:122090102 | WDR5B | chr3:122130700-122134882:- | 0.18 | 5.1 | 3.98E-7 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11920900 | chr3:49823024 | CCDC36 | chr3:49235861-49295537:+ | 0.09 | 3.53 | 0.000437 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11920900 | chr3:49823024 | DALRD3 | chr3:49052435-49058467:- | 0.13 | 4.22 | 2.68E-5 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11920900 | chr3:49823024 | P4HTM | chr3:49027341-49044579:+ | 0.08 | 3.6 | 0.000336 | Resting heart rate |